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| Advisor(s) | Bangun, Sofia Eliasari Br | |
| Author(s) | HUTASUHUT, ANNISA DARMAWITA | |
| Issued Date | 2026 | |
| Abstract | Pegagan leaves (Centella asiatica) are a medicinal plant known to contain secondary metabolites—such as flavonoids, phenolics, and triterpenoids—that possess potential antioxidant activity. The dangers posed by free radicals have recently become a frequent topic of discussion. Pegagan leaf extract can serve to protect and stabilize the body against free radicals, acting as an antioxidant that may aid in addressing conditions such as heart disease, stroke, diabetes, Parkinson's disease, Alzheimer's disease, atherosclerosis, neurodegenerative disorders, and cancer. This study aimed to determine the differences in antioxidant activity between fresh and dried pegagan leaf extracts, using vitamin C as a reference standard. The results showed IC₅₀ values of 14.80 ppm for fresh pegagan leaf extract, 13.10 ppm for dried pegagan leaf extract, and 10.88 ppm for vitamin C. Based on antioxidant activity classifications, both extracts fell into the "very strong" antioxidant category (IC₅₀ < 50 ppm); however, the dried pegagan leaf extract exhibited higher antioxidant activity, as evidenced by its lower IC₅₀ value compared to the fresh extract. Method validation results indicated that the method met all requirements, demonstrating an accuracy of 107,68 %, precision (%RSD) of 0.71%, linearity with a coefficient of determination (R²) of 0.9894, an LOD of 1,305 ppm, and an LOQ of 3,95 ppm. In conclusion, the study found a difference in antioxidant activity between fresh and dried pegagan leaf extracts obtained via the decoction method. The UV-Vis spectrophotometric 2,2’-azino-bis (3 ethylbenzothiazoline)-6-sulphonic acid (ABTS) method meets method validation requirements, making it suitable for determining the antioxidant activity of Centella asiatica leaf extract. | 1 |
| Item Type | Skripsi | |
| Keywords | Centella asiatica, Daun Pegagan (Centella asiatica leaves) , Aktivitas Antioksidan (Antioxidant activity ), Dekokta (Decoction), ABTS(2,2’-azino-bis (3 ethylbenzothiazoline)-6-sulphonic acid ), Spektrofotometri UV-Vis(UV-Vis Spectrophotometry) , Validasi Metode(Method Validation) | 1 |
| Collection | Fakultas Farmasi, S1-Farmasi | |
| Publisher | INSTITUT KESEHATAN DELI HUSADA | |
| Submitted Date | 25-08-2026 | |
| Updated Date | 26-08-2026 | |
| URI | No URI | |
| File |
2218017_ANNISADARMAWITAHUTASUHUT_SKRIPSI_S1 (1).pdf
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