Informasi ringkas dokumen repository.
| Advisor(s) | Purba, Gratia Apulina Cindylawsa | |
| Author(s) | YOLANDA, MEYLA | |
| Issued Date | 2026 | |
| Abstract | Determination of Valsartan and Amlodipine Levels in Combination Tablet Dosage Forms Using the Area Under Curve (AUC) Method by UV-Visible Spectrophotometry. 2026. Undergraduate Thesis, Bachelor of Pharmacy Study Program, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua (Supervised by apt. Gratia Apulina Cindylawsa Purba, S.Farm., M.Farm.). Valsartan and amlodipine are widely used in combination for the treatment of hypertension. Quality control of combination tablet dosage forms requires an analytical method that is accurate, simple, and efficient. This study aimed to determine the levels of valsartan and amlodipine in combination tablet dosage forms using the Area Under Curve (AUC) method by UV-Visible spectrophotometry and to validate the analytical method based on the parameters of linearity, precision, accuracy, limit of detection (LOD), and limit of quantitation (LOQ). This experimental study included the determination of the maximum absorption wavelengths, measurement of the absorption spectra of valsartan, amlodipine, and their mixed standard solutions, determination of the Area Under Curve within the wavelength ranges of 245–255 nm for valsartan and 232–242 nm for amlodipine, construction of calibration curves, quantitative determination of drug content in combination tablet dosage forms, and validation of the analytical method. The results showed that the calibration curves of valsartan and amlodipine exhibited excellent linearity with correlation coefficients (r) of 0.999 for both compounds. The average assay results were 100.26 ± 2.9055% for valsartan and 101.50 ± 9.4673% for amlodipine, indicating compliance with the assay specifications of the Indonesion Pharmacopoeia VI Edition. The validation results demonstrated that the method fulfilled the acceptance criteria for precision, accuracy, limit of detection, and limit of quantitation. It can be concluded that the Area Under Curve (AUC) method using UV-Visible spectrophotometry is suitable for the quantitative determination of valsartan and amlodipine in combination tablet dosage forms, complies with the requirements of the Indonesion Pharmacopoeia VI Edition, and can be applied as a reliable analytical method for routine quality control of pharmaceutical preparations. Keywords: Valsartan, amlodipine, area under curve (AUC), UV-Visible Spectrophotometry, validation | 1 |
| Item Type | Skripsi | |
| Keywords | Valsartan (Valsartan), Amlodipin (Amlodipine), Area Under Curve (Area Under Curve), Spektrofotometri UV-Vis (Spectrophotometric UV-Visible), Validasi (Validation) | 1 |
| Collection | Fakultas Farmasi, S1-Farmasi | |
| Publisher | INSTITUT KESEHATAN DELI HUSADA | |
| Submitted Date | 04-09-2026 | |
| Updated Date | 04-09-2026 | |
| URI | No URI | |
| File |
2218111_MEYLAYOLANDA_SKRIPSI_S1.pdf
Login untuk Preview
|
|