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| Advisor(s) | apt. Angga Nugraha Sanjaya, S.Farm., M.Farm. | |
| Author(s) | DWI DEFRI AGUSTINA SARI | |
| Issued Date | 2026 | |
| Abstract | Acne is a common skin disorder primarily caused by the bacterium Cutibacterium acnes. Breadfruit (Artocarpus altilis) leaves contain secondary metabolites, including flavonoids, alkaloids, tannins, saponins and steroids, which have the potential to exhibit antibacterial activity. This study aimed to formulate an ethanol extract of breadfruit leaves into an acne patch and to evaluate its physical quality and antibacterial activity against Cutibacterium acnes. This research was an experimental laboratory study using several formulations with different extract concentrations. The resulting acne patches were evaluated for organoleptic properties, weight uniformity, folding endurance, thickness pH and stability. Antibacterial activity was determined using the disc diffusion method and the data were analyzed statistically using One-Way Analysis of Variance (ANOVA) followed by the Post Hoc Tukey test. The results showed that all acne patch formulations containing breadfruit leaf ethanol extract met the required physical evaluation parameters, including organoleptic properties, weight uniformity, folding endurance, thickness, pH and stability. During the observation period, no changes in color, odor, or shape were observed, indicating good physical stability. All formulations demonstrated antibacterial activity against Cutibacterium acnes, as evidenced by the formation of inhibition zones around the test discs. The formulation containing the highest concentration of breadfruit leaf ethanol extract (FIII) produced the largest inhibition zone, indicating the strongest antibacterial activity among all formulations. In conclusion, the acne patch containing ethanol extract of breadfruit leaves (Artocarpus altilis) fulfilled the required physical quality parameters and exhibited antibacterial activity against Cutibacterium acnes. The FIII formulation was identified as the most effective formulation. Keywords: Acne Patch, Artocarpus Altilis, Breadfruit Leaf Ethanol Extract, Cutibacterium Acnes, Antibacterial Activity. | 1 |
| Item Type | Skripsi | |
| Keywords | Plester jerawat (Acne Patch), Artocarpus altilis (Artocarpus Altilis), ekstrak etanol daun sukun (Breadfruit Leaf Ethanol Extract), Cutibacterium acnes (Cutibacterium Acnes), aktivitas antibakteri (Antibacterial Activity) | 1 |
| Collection | S1-Farmasi | |
| Publisher | INSTITUT KESEHATAN DELI HUSADA | |
| Submitted Date | 20-10-2026 | |
| Updated Date | 20-10-2026 | |
| URI | No URI | |
| File |
Skripsi DWI DEFRI AGUSTINA SARI.pdf
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